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Analysis of a cohort of 874 patients who underwent lumbar spinal fusion found that at 24 months post-surgery, an alarming 44.4% of patients had been prescribed opioids for continued pain management and 37.8% of patients were receiving mental health treatment for stresses related surgery and back pain (McMillan et al., 2021)

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The adrenal glands generate hormones such as glucocorticoids, mineralocorticoids, and androgens, ( Figure 1 ) which play significant roles in regulating various physiological processes (55)