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This local hepatic inflammation leads to further recruitment of systemic inflammatory cells, such as neutrophils, T-cells and monocytes, which perpetuate additional inflammation, hepatic fibrosis, hepatocyte cell death (68, 72, 73) that ultimately leads to rapid progression to multiple organ failure (74)

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This AOP identifies the deposition of ionizing energy as the MIE, leading to DSB and subsequent mutations due to the errors in DNA repair mechanisms

10.1111/j.1600-0625.2007.00613.x 228

RAMSES 2025: The 13th Annual Robotic Assisted Microsurgical & Endoscopic Society Symposium