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There are four hypotheses regarding HLA-related pathogenesis in AS: The arthritogenic peptide theory, the misfolding theory, the homodimer theory, and the mimicry theory

Graphical abstract Hydrogel-enabled drug delivery systems offer a comprehensive therapeutic approach for ulcerative colitis, demonstrating therapeutic outcomes Access this article Similar content being viewed by others Data availability All data generated or analyzed during this study are included in this published article

The process involves the activation of thymine DNA glycosylase, Myc's transcriptional target, causing the Glutamine synthetase (GS) promoter to undergo active demethylation and exhibit higher expression

It is mainly manifested in the many aspects, they improved energy metabolism, suppressed OS and inflammation, and modulated the Wnt-1/-catenin and PTEN/PI3K/Akt pathways ( Extracellular polysaccharides (EPS) from Pleurotus eryngii SI-04 exhibited anti-glycated activities in STZ-regulated diabetic mice

Comparison of the GOBP category cell redox homoeostasis showed greater overlap between the two conditions (Fig