chac1 glutathione (GSH) depletion by results in a more oxidizing L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated
L 2 Hydroxyglutarate sensitizes ferroptosis through ATF3 CHAC1 mediated glutathione degradation in hepatocellular carcinoma Cell Death & Disease Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv Frontiers CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers Functions of glutathione degrading enzymes in tumors. The functions of Download Scientific Diagram Frontiers Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death
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