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Impressively, 59% of chemo-resistant patients showed response

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Additionally, the hypoxia-inducible factor-1 (HIF-1) acts as a pivotal regulator during hypoxic and ischemic conditions, playing a key role in promoting cell survival and driving the production of pro-inflammatory cytokines

For example, certain gut bacteria, such as Bifidobacterium breve and Lactobacillus plantarum , can participate in the synthesis and regulation of neurotransmitters like acetylcholine, dopamine, serotonin, and GABA, as well as their precursors, in specific gut cells such as enterochromaffin cells (175)

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