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613,614 Astrocytes in AD animal models, as well as astrocytes differentiated from stem cells isolated from AD patients, are characterised by decreased energy metabolism, decreased glucose uptake and glucose consumption

Certain gut bacteria, including Bacteroides , Bifidobacterium , Prevotella , Faecalibacterium , Lactobacillus , and Parabacteroides , ferment indigestible polysaccharides into short-chain fatty acids (SCFAs)such as butyrate, acetate, and propionatewhich enhance epithelial barrier integrity and reduce gut permeability, thereby preventing microbial translocation to extraintestinal tissues [100, 101]

Using succinate as an example, the k value was calculated to be 0.0011 min 1 , with an r value of 0.991 (Supplementary Fig

Reconstitution with bacteriostatic water is typical for research handling

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