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Conditions affecting any stage of this absorption pathwayincluding pernicious anaemia (an autoimmune condition destroying intrinsic factor-producing cells), Crohn's disease, coeliac disease, or surgical removal of stomach or ileal tissuecan significantly impair B12 absorption despite its water-soluble properties

was supported by grants from the Canadian Institutes for Health Research and the National Institute of Health

According to the World Health Organization (WHO), about 75% of the affected individuals do not get proper treatment for the management of epilepsy, and this percentage has also reached 90% in some low-income countries, as these anti-epileptic drugs (AEDs) are inaccessible, too expensive, or have unwanted side effects (ODonohoe et al., 2020

X., Wang, X., Fam, J., & Kim, J

Lancet 395 , 709733 (2020)