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Studies using minocycline in light-induced retinal damage models and their impact on microglial cells have varied showing both a decrease in immunolabeling of CD11b of microglial cells, which may protect against loss of photoreceptors through inhibition of retinal microglia activation, and a delay in photoreceptor cell death, which was independent of a reduction in retinal microglial cells, following depletion of microglia cells using liposomal chlodronate (Yang et al., 2009