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As most published TB-500 research to date has involved rodents, there is limited data from which to calculate TB-500 dosage in an experimental setting

Increased levels of the neurotransmitter N-terminal pro-brain natriuretic peptide (NT-proBNP), increased regurgitated jet velocity of the tricuspid valve on echocardiography, and elevated pulmonary pressures on right cardiac catheterization are among the diagnostic findings [49]