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These applications span acute diarrheal diseases, IBS, a variety of bacterial and viral infections (including HIV and HPV), obesity, insulin resistance syndrome, type 2 diabetes, NAFLD, cancer, allergic disorders, neurological conditions, and lactose intolerance (342, 343)

169 Additionally, overexpression of HSPA5 inhibits ferroptosis through the P53/SLC7A11/GPX4 pathway and may serve as a novel biomarker and potential therapeutic target

To advance clinical translation, we recommend prioritized efforts in three interrelated areas: (i) standardized, reproducible formulation and dose-finding studies integrating pharmacokinetics and pharmacodynamics (PK/PD)