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238,242 Isocitrate dehydrogenase 3 (IDH3), a pivotal rate-limiting enzyme in the TCA cycle, is downregulated, leading to oxidative phosphorylation uncoupling and lactate accumulation in the brains of AD patients and AD transgenic mice

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And avoid exposing it to direct light, which accelerates photodegradation of the peptide structure

Dirksen, U

Diarrhea or Constipation Changes in bowel habits may emerge but usually stabilize once the body adapts to the medication