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After the microneedle is inserted into the psoriatic skin, the needle tip separates from the base, and MTX is rapidly released from the swollen gel pores, promptly inhibiting keratinocyte proliferation, while EGCG breaks the bond in response to the high ROS environment in the skin and releases in an intelligent and controlled manner, effectively inhibiting the NF-B inflammatory pathway for a long time ( Although antioxidants have a strong ability to remove ROS, the poor stability and difficulty in penetrating the cell membrane limit their clinical development and application

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Discovered in 2015, it has become a central tool in research on AMPK signalling, metabolic homeostasis, and mitochondrial-nuclear crosstalk

Ginger also inhibits NF-B activation, decreases TNF, IL-6, and IL-1 expression, and mitigates ROS production

2023 Aug 1;6(8):e2327739