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Additionally, it normalizes the PPA-induced increase in brain-derived neurotrophic factor (BDNF) transcript levels in the hippocampus, further supporting neuroplasticity and cognitive recovery (Abuaish et al., 2021)

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The most recent study further confirmed that ApoE glycosylation profiles are isoform-specific, with a lower extent of ApoE4 glycosylation in CSF but not in plasma (Meuret et al., 2023)