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22 Insulin signaling pathways Physiologically, insulin binds to the extracellular subunit of insulin receptor, a receptor tyrosine kinase which recruits and phosphorates insulin receptor substrate (IRS)-1, thus activating phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling and diverse downstream pathways to maintain the glucose homeostasis

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Dystrophin Gene in Duchenne Muscular Dystrophy: The Genetic Cause The dystrophin gene in Duchenne muscular dystrophy is mutated, resulting in little or no production of functional dystrophin protein