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The contemporary view is that IGFs serve dominant roles in cell proliferation, survival and organismal growth, whereas insulins primary functions include the regulation of fuel accumulation, storage and energy expenditure

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Since studies using conditional knockout mice indicate that muscle, but not hepatic, IGF1 is a critical factor for skeletal growth (Bikle et al., 2015), it is possible that L-carnitine activates the mTOR signaling by increasing local IGF1 production

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Anxiety disorders in long-term survivors of adult cancers