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In the combined therapy, IMiDs increase the direct toxic effects of CD38 mAbs, including lysosomal-mediated apoptotic pathways, and increase CD38 expression on Treg cells, resulting in enhanced elimination of Treg cells [96, 97]

15 That said, both Pearlman and Calvert strongly advise against combining clomiphene citrate with higher doses of conventional TRT, especially injections

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Aliquoting reconstituted material into single-use volumes at the time of initial reconstitution is the standard research practice