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COP1 interacts with multiple substrates either directly or indirectly using accessory proteins and targets them for UPS-mediated degradation

In neurons, STING serves as a targetable central driver that sits at the convergence of neuroinflammation and ionic disruption, underpinning the progression of neurodegeneration (158)

In addition to the tight junctions, the intestinal epithelium is covered by a protective mucus layer, which plays a crucial role in the intestinal defense mechanism

Buda V, Sturza A, Minda D, Diaconeasa Z, Iuhas C, Bdescu B, Dehelean CA, Danciu C, Muntean MD, Lighezan R, Dnil MD (2024) Vasculo-protective effects of standardized black chokeberry extracts in mice aorta

Studies have shown that a combination of high-dose oral and rectal mesalazine therapy is more effective at inducing remission of mild-to-moderate symptoms compared with oral therapy alone