Disclosures: Paul Hayashi: Nothing to Disclose, Jasmine Amirzadegan: Nothing to Disclose, Edwige Chiogo Vouffo: Nothing to Disclose, Ling Lan: Nothing to Disclose, Eileen Navarro Almario: Nothing to Disclose, Mark Avigan: Nothing to Disclose 2646 THE PROTECTIVE ROLE OF SULFIREDOXIN-1 (SRXN1) IN ACETAMINOPHEN-INDUCED LIVER INJURY mengyun ke 1 Jongwon Kim 1 Kate S Carroll 2 Wen Xie 1 , 1 University of Pittsburgh, 2 UF Scripps Biomedical Research Background: Acetaminophen (APAP)-induced liver injury is the leading cause of acute liver failure in many Western countries
Nature 573 (7772), 135138
This acidic environment, although ideal for digestion, causes the bonds between the three amino groups of glutathione to dissolve, resulting in the remints being excreted
Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping
5 Selective autophagy and ferritinophagy in lesion redox control Autophagy is a critical cellular quality control process with a complex, double-edged role in cell fate: it can promote survival by recycling damaged components or contribute to cell death under specific forms of stress