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Faienza, F., Rizza, S., Giglio, P

In the animal model, iron chelator Deferiprone (DFP) improves myocardial mitochondrial function, and Liproxstatin-1 (Lip-1), a specific inhibitor of ferroptosis, also protects the integrity of mitochondrial structure (Ravingerov et al., 2020

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Notably, persistent (i.e., drug-tolerant) cancer cells are particularly vulnerable to GPX4 inhibitors

For the mitochondrial MRP-1::GFP colocalization experiment, MRP-1::GFP transgenic L4-stage animals were exposed to 0.5 l of MitoTracker Red dye (1 g/l concentration) prepared in 1 ml of M9 buffer