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However, unfavorable effects of ALDH2*2 allele have been reported in terms of the risk of some diseases such as osteoporosis [25] and neurodegenerative diseases [24, 26, 27]

NTZ, especially at the higher dose, elicited similar hepatoprotective effects comparable to NAC and 4-PBA, indicating the possible involvement of ER stress modulation in NTZ-elicited hepatoprotective effects

Recent studies have also explored the use of combination therapies that incorporate novel agents targeting specific cellular mechanisms, such as mitophagy ( Future research may focus on identifying optimal drug combinations tailored to individual patient profiles

[DOI] [PMC free article] [PubMed] [Google Scholar] 217.Zmb V., Simon-Szab L., Szelnyi P., Kereszturi ., Bnhegyi G., Csala M

The acquired mutations were enriched for the mutational signatures (SBS2) and SBS13 that have been attributed to apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) cytidine deaminase activity