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In contrast, AMPs have significant advantages in anti-tumor as they offer a wide range of antimicrobial and anticancer spectrum, high selectivity to cancer cells, harmlessness to normal cells and important organs, and low propensity to develop drug resistance

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575 Similarly, the loss of mitochondrial complex I leads to a decrease in the ratio of NAD + /NADH and can inhibit the activity of Sirt3, thereby enhancing the protein acetylation and mPTP sensitivity