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10.1172/JCI20208 69

All SLC2As have 12 membrane-spanning helices and several conserved sequence motifs, yet they exhibit tissue-specific distribution, kinetics, and substrate specificity ( Figure 1 )

Therefore, adding L-Carnitine to culture medium does not automatically guarantee equivalent intracellular carnitine availability across all experimental models

Genomic screening identified Solute Carrier Family 7 member 11 (SLC7A11) as a mediator of TS resistance, suggesting combined targeting may further enhance the pro-oxidant activity of RSO-021