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Due to the high prevalence of vitamin D deficiency secondary to exocrine pancreatic insufficiency, it is a common practice to supplement vitamin D in the population of patients with cystic fibrosis

TNF- impairs barrier function by increasing epithelial cell shedding and downregulating occludin expression [78, 79], whereas IFN- increases permeability by inducing STAT1-dependent TJ remodeling [80]