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Basically, Ni in aquatic ecosystems combines with other chemical compounds to form soluble salts that have the ability to adsorb onto other substances and cause several synergistic and antagonistic effects [141]

While iron overload and lipid peroxidation are common features of ferroptosis across malignancies, the specific involvement of thyroid-specific molecules like GPX4 and SLC7A11 in regulating ferroptosis pathways in thyroid cancer is more pronounced ( Figure 8 Furthermore, the interplay between ferroptosis and immunotherapy constitutes an innovative approach to cancer treatment

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