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Elevated levels of lactate in the TME hinder the export of lactate from human CTLs, consequently impeding the proliferation and cytotoxic effects of CTLs

The reliability of these results was confirmed by the implementation of known enkephalinase inhibitors in the experiment, which gave the above results

However, oral supplementation of L-arginine, the precursor for NO synthesis, has been shown to be largely ineffective at increasing NO synthesis and/or bioavailability for several reasons, which makes L-citrulline much more ideal for boosting levels of L-arginine and subsequently NO

Antibiotic-induced microbiome-depleted in butyrate-producing microbiota is associated with type 2 diabetes 22

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