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This progress can lead to iron overload and elevate ROS in mitochondria, triggering lipid peroxidation and cardiomyocyte ferroptosis ( 4 Targeted therapy of ferroptosis in cardiovascular disease Inhibiting ferroptosis-related targets has excellent therapeutic potential for treating and preventing heart disease, based on research into the pathogenesis of these conditions

Individuals with inherited defects in selenocysteine insertion sequence (SECIS)-binding protein 2 display a syndrome of selenoprotein-related defects including abnormal thyroid hormone metabolism, delayed bone maturation, and other more individual phenotypes

4b), a substantial drop in the GSH/GSSG ratio (Fig

Heart Health: Some research suggests that it may have positive effects on cardiovascular health

doi: 10.1371/journal.pone.0252930 86 NorlinAKWalterSIcenhourAKeitaVElsenbruchSBednarskaOet al