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Consistent with this mechanism, AB4 and the RAGE inhibitor FPS-ZM1 reversed Nrf2 depletion in vivo , restoring GPX4 and SLC7A11 expression

SCFAs are synthesized predominantly in the cecum and ascending colon, where they play roles in modulating food absorption, altering the gut pH, supporting immune function, and maintaining overall gastrointestinal health and stability (Litvak et al., 2018)