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Furthermore, oxidative stress and inflammation mutually reinforce each other (25), with inflammatory cells producing ROS exacerbating oxidative stress, while ROS and oxidative stress products promote inflammatory responses

Pharmacokinetic studies show that oral NAC reaches peak blood levels within one to two hours, with therapeutic concentrations maintained for several hours

It also contributes to anti-aging effects by supporting collagen production and improving skin texture

This effect is further compounded by the inactivation of glutathione peroxidase 4 (GPX4) as ONOO can modify the selenocysteine residue within its active site, thereby disabling the only enzyme capable of directly reducing complex lipid hydroperoxides in biological membranes

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