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These PPP abnormalities ultimately impact cellular function: for example, neutrophils in COPD patients primarily rely on glycolysis for energy, with both the PPP and glycolysis supplying energy and NADPH for the formation of neutrophil extracellular traps (NETs)

Additional reference Sir Frederick Gowland Hopkins Sir Frederick Gowland Hopkins was awarded the Nobel Prize in Physiology or Medicine in 1929, with Christiaan Eijkman, for the discovery of vitamins

Hosein et al., 2012) didnt display any toxicity profile related to renal dysfunction at dose-limiting toxicity (DLT)

Thesis, Freie Universitt Berlin, Berlin, Germany, 1997

It should be mentioned that the present study is limited by the relatively small cohort size