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It is pharmacologically real, not a placebo step, but it is placed low so the gut can adapt before the effective doses arrive

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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study

Side effects are rare but can include minor issues like redness or swelling at the injection site