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For comparison, we treated cells with tunicamycin (TUN, a widely-used ER stress inducer) which did not alter phospho-GCN2 (T899), but reduced the mobility of PERK, indicative of its increased phosphorylation (Fig

The accumulation of mercury in fetuses was found to be dose dependent, however, no statistically significant effects on fetal brain weights or on fetal body weights were noted even with fetal mercury concentrations reached a mean of 108.8 ng Hg/fetus (whole body) on GD 10 (the only day on which whole body burden was examined) and 1.93 ng/brain by GD 15