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Front Neurosci 13:654

A high-methionine diet (HMD) caused hyperhomocysteinemia (HHcy) and HS in mice

Said differently, to significantly advance how we treat bipolar disorder, we will need to replace unidimensional (i.e., purely phenomenological diagnoses) and static (i.e., based on the assumption that the appearance and underlying pathophysiology of the disease do not evolve over time) diagnostic and treatment approaches with strategies that are dynamic and integrated (i.e., including elements such as psychotherapy, pharmacotherapy, exercise, nutrition, meditation, relationship healing, etc.) as well as multi-level (i.e., based on phenomenology, neuroimaging, and biochemical and genetic evaluation)

Radiotherapy can not only kill tumor cells directly, but also induce ICD and release DAMPs, thus activating the immune system

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