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Mechanistically, we present the first direct evidence of a transcriptional negative regulatory relationship between Stat1 and Nrf2, with Crizotinib promoting this transcriptional activity, suggesting that inhibiting Stat1 could offer an intriguing intervention strategy

Valproic acid and thalidomide induce morphological abnormalities in the brain, such as reducing cranial motor neurons and modifying cerebellar structures [214, 215]