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While in 1015% X-ALD patients who develop cerebral demyelination spontaneous arrest of demyelinating process occurs with unaltered blood-brain barrier, majority of cALD patients show disrupted blood-brain barrier

[DOI] [PubMed] [PMC] Agil A, Navarro-Alarcon M, Ali FAZ, Albrakati A, Salagre D, Campoy C, et al

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Oxidative stress activates multiple transcription factors, including hypoxia-inducible factor-1 (HIF-1), AP-1, NF-B, p53, and nuclear factor erythroid 2-related factor 2 (Nrf2) (Reuter et al., 2010)

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