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In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsons disease mouse model, treatment with Lf-ASX-LPs resulted in 5.0-, 3.1-, and 5.6-fold increases in dopamine levels, TH + fiber density, and TH + neurons, respectively, restoring dopaminergic neuron damage

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In clinical practice, treatment is considered in patients able to walk independently, in case of bulbar or respiratory involvement, when dysautonomia occurs, when there is disabling upper limb weakness, or in the presence of rapid decline [39]