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Description

JAMA 309.12 (2013): 1241-1250

Hydrogen sulfide in paraventricular nucleus attenuates blood pressure by regulating oxidative stress and inflammatory cytokines in high salt-induced hypertension

At physiological flux, H 2 S/RSS protect by (1) persulfidating catalytic cysteines (SSH), stabilizing reversible thiol switches, (2) reducing sulfenylated intermediates (CysSOH) back to active thiols and (3) modulating mitochondrial electron flow via the SQR pathway (Andrs et al