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Nguyen T, Nioi P, Pickett CB (2009) The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

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Figure 2 The pathophysiology of ED Penile erection is a hemodynamic process accomplished by the corpus cavernosum under the joint action and mutual coordination of neurological, endocrine, and psychological factors, and is also influenced by multiple factors such as drugs, age, lifestyle habits, and systemic diseases ( Age is the most common risk factor in ED, the prevalence and the severity of ED increases with age, and age-related ED is one of the main types of ED being studied ( Diabetes is the second most common risk factor for ED, with more than 50% of diabetics having ED as a complication and approximately 12% of patients with diabetes having ED as a first symptom ( Neurogenic ED is also the more commonly studied type of ED currently