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Beyond tumorintrinsic effects, lactylation also modulates immune cell function directly, for example, H3K18la upregulates the immunosuppressive molecule B7H3 in CD8 + T cells, inducing T cell exhaustion (78, 79)

These include the combination of casirivimab and imdevimab, the combination of bamlanivimab and etesevimab, and sotrovimab (Table 2)

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