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Evidence for peroxisomal dysfunction and dysregulation of the CDP-choline pathway in myalgic encephalomyelitis/chronic fatigue syndrome

These data point to a previously unrecognized effect of KG-mediated epigenetic rewiring through histone acetylation

226 Although it is still unclear whether hearing loss is the cause of changes in brain structure and function, intriguing evidence has shown individuals with prolonged hearing loss experience shrinkage of certain brain regions

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By conducting in-depth analysis of the diet-microbiota-immunometabolism regulatory network, through targeted dietary modifications to adjust nutrient availability in the TME, reshaping the gut microbiota with probiotics or prebiotics to enhance immunometabolic activity, and combining immune checkpoint inhibitors with metabolism-targeted drugs, it may be possible to disrupt tumor metabolic adaptation and immune escape at a systemic level, thereby achieving personalized and precision therapy