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In thesis, obesity-related metabolic dysfunction could hinder the expected epigenetic responses, potentially due to factors such as increased folate utilization, higher urinary excretion, blood volume dilution, tissue distribution differences, and endocrine alterations [41, 42]

27 Unfortunately, despite having many beneficial effects for overall health, metformin is not universally well tolerated with the adverse effects primarily reported to be the result of gastrointestinal (GI) intolerance

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