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A significant higher infiltration of immune cells such as macrophages and lymphocytes and pro-inflammatory factors IL-6 and TNF- has been detected in PCOS organ systems, impacting not only the female reproductive system but also other organs such as the cardiovascular, intestine, liver, thyroid, brain and other organs

92 Resveratrol also inhibits circulating oncogenic microRNAs (miRs) such as miR-19, miR-21, and miR-30a-5p, thereby suppressing the expression of genes that code for epidermal growth factor receptor, signal transducer and activator of transcription, COX-2, and downregulating the mTOR signaling pathway

This potential restoration of p53s function by the FOXO4-DRI peptide might enable it to trigger the programmed cell death of senescent cells, essentially clearing out cells that might otherwise contribute to the decline in tissue function seen in aged cell cultures

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lated compounds with vitamin K activity