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Siddiqui B, Rehman AU, Haq IU, Al-Dossary AA, Elaissari A, Ahmed N

APOE4 carriers display earlier reductions in brain glucose metabolism (Reiman et al., 1996) and studies have linked APOE4 to changes in brain mitochondrial dynamics (Schmukler et al., 2020

Suppresses NF-B signaling and the pro-inflammatory cytokines

3.5.4 Macrophage ferroptosis and SLE Renal M2-like macrophages in LN patients selectively express CD163 (haptoglobinhemoglobin complex scavenger) and SLC40A1, tied to iron homeostasis (219, 220): 1) SLE-associated autoimmune hemolysis and glomerular injury-induced erythrocyte lysis generate excess haptoglobinhemoglobin complexes

Bimzelx is a humanized IgG1 monoclonal antibody designed to target the IL-17A and IL-17F cytokines, which are known to play key roles in immune and inflammatory cascades