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We developed a cellular senescence assay for in-chip measurements by adapting the Cellular Senescence Detection Kit SPiDER-Gal (Dojindo Molecular Technologies, Inc

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The major ROS-generating systems in the vascular wall include NADPH oxidase, xanthine oxidase, the mitochondrial electron transport chain, and uncoupled endothelial nitric oxide (NO) synthase ( 5.3.2 Endothelial dysfunction It has been shown that feeding mice a curcumin chow mix (0.1% curcumin + HFD) not only controls body weight gain but also enhances HO-1 enzyme activity in aortic tissues and maintains Sirt1 expression, contributing to the inhibition of oxidative stress in the vasculature and throughout the body (Takano et al., 2018)

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