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If, during the cardiovascular evaluation, the patient's medical history or electrocardiographic investigations reveal findings indicative of or consistent with coronary artery vasospasm or myocardial ischemia, dihydroergotamine mesylate nasal spray should not be administered (see CONTRAINDICATIONS)

Neuroprotective: Provides antioxidant protection to help reduce oxidative stress on neurons

Webster R, Didier E, Harris P, Siegel N, Stadler J, Tilbury L, et al

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid

As physicians and scientists, we have to ask ourselves and answer the questions: Is it effective for that specific use