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Zhang H, Yue X, Chen Z, Liu C, Wu W, Zhang N, et al

They stand out thanks to their high sensitivity, quick response, and ability to scale

However, while current findings are encouraging, more rigorous clinical trials are essential to confirm their efficacy, determine optimal dosages, and assess long-term safety profiles

It is undergoing Phase III trials to evaluate its safety in treating DED caused by dry eye syndrome (NCT05310422 and NCT04819269)

Interestingly, a recent study showed that despite the low plasma concentration of polyphenols, polyphenols were transported to the arterial intima at pH 7.4 in the form of bound lipoproteins, and polyphenol levels were significantly elevated in endothelial cells and macrophages (148)