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For methylation-focused applications, the Illumina 5-base solution requires less sequencing than standard methylation assays due to greater mapping efficiency and CpG coverage per run

Oxidative stress damages the DNA, which results in neuronal cell death 14

Singapore Med J 59:170 Tiezzi F, Brito LF, Howard J, Huang YJ, Gray K, Schwab C, Fix J, Maltecca C (2020) Genomics of heat tolerance in reproductive performance investigated in four independent maternal lines of pigs

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BBB is also a major hurdle for the tumor cells in their way to the metastasis and colonizing in the brain tissue