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Intravenous administration leads to a significant elevation in plasma glutathione levels compared to oral supplementation - particularly in patients with impaired absorption or a high oxidative burden

Inadequate intake of specific nutrients slows cell turnover, disrupts melanin regulation and increases oxidative stressall of which can manifest as hyperpigmentation

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354,355 It has been postulated that inhibitors conforming to the substrate envelope exhibit a superior resistance profile by safeguarding against binding site mutations, which would otherwise impede access to the substrate envelope and significantly compromise natural substrate binding

10.1016/j.biochi.2017.10.002 194 ZhangS.ZhongR.TangS.ChenL.ZhangH