Gelam honey markedly inhibited these pathways in HIT-T15 pancreatic islet cells at concentrations as low as 20 g/mL ( In vivo , oral administration of Malasyian gelam honey (12 g/kg) reduced leukocyte infiltration and edema in carrageenan-induced rats, thus attenuating acute inflammatory responses ( Tualang honey, collected by Apis dorsata bees from Malaysian rainforests, is especially abundant in phenolic acids and flavonoids
In the transition metal chelation mechanism, polyphenol anions chelate heavy metals through the deprotonation of hydroxyl groups, forming metal complexes and releasing a proton (ArOH ArO + H+) (160)
By adding L-theanine to the drinking water of cirrhotic rats established by carbon tetrachloride, it was found that L-theanine inhibited the expression of NF-B, downregulated the pro-inflammatory cytokines (e.g., IL-1 and IL-6), and profibrotic mediators (e.g., transforming growth factor and connective tissue growth factor), and promoted the expression of anti-inflammatory cytokine IL-10 and fibrinolytic enzyme metalloproteinases-13 (85)
Nanomaterial-based drug delivery systems (NBDDS) utilize nanoparticles for improving drug effectiveness and safety
Sun drying may take as long as 3 days for each iteration to attain thorough desiccation, whereas hot air drying (HAD) only requires 12 h per cycle at a temperature of 60C (97)
