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A significant increase in ferritin level promoted the progression of OA and was positively correlated with the severity of arthritis ( Figure 3 ) (102, 103)

The antioxidant effects of curcumin can reduce oxygen radicals produced in vivo , induce antiapoptotic effects, and resist myocardial infarction-induced cardiac dysfunction (Lv et al., 2016)

In addition, iron overload was found to significantly increase lung inflammation and oxidative stress in mice, which are also crucial mechanisms underlying pulmonary fibrosis (111)