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Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome

Higher therapeutic doses (20003000mg) are sometimes used short-term under supervision

In the context of Long COVID and ME/CFS, a functional B12 deficiency can lead to demyelination, where the protective coating of the nerves begins to degrade

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Zhang X, Xie X, Heckmann BL, Saarinen AM, Gu H, Zechner R, et al

CD38 inhibition, resulting in increased NAD + levels, may slow aspects of the aging trajectory and enhance immune function, making it a promising area of research for various diseases 137,138